Adie Lab

Lin’s talk was entitled “High-throughput lightsheet optical manipulation and measurement with optical coherence tomography”.  Further details can be found at https://www.osapublishing.org/abstract.cfm?uri=OCT-2020-OTu1E.4.

The paper, entitled “Obesity-associated Adipose Stromal Cells Promote Invasion of Premalignant Breast Cancer Cells Through ECM Remodeling”, used 4D-OCM to quantify differences in cell-induced extracellular matrix (ECM) deformations between tumor spheroids co-cultured with lean vs. obese adipose stromal cells (ASCs).

Jeffrey A. Mulligan, Lu Ling, Claudia Fischbach-Tesch, Steven G. Adie, “4D traction force optical coherence microscopy for the analysis of tumor spheroid growth and invasion in collagen”.

Nichaluk Leartprapun, Yuechuan Lin, and Steven G. Adie, “Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity”.

The paper, entitled “Computed optical coherence microscopy of mouse brain ex vivo“, utilizes computational adaptive optics to reconstruct high-resolution volumes from 4X fewer datasets than standard focus-shifting optical coherence microscopy.

The paper, entitled “Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography“, shows that localized ARF excitation with a smaller acoustic focal spot size results in strain elastograms with superior spatial resolution, contrast, and contrast-to-noise ratio.

See https://research.cornell.edu/news-features/imaging-tracking-cancer-cell-invasion

Check out the new Buttermilk State Park photos listed under “Outdoor adventures around Ithaca” in our Gallery page.