Author: Steven Graham Adie

This new grant will support our collaborative research with the Xu Group on the development of multimodal hybrid adaptive optics.  We seek to utilize computational adaptive optics (CAO)-OCT as a deep-tissue aberration sensor, together with the close connection between hardware AO and CAO, to enable AO three-photon microscopy (AO-3PM) image faster and deeper  in the mouse and adult zebrafish brain (collaboration with the Fetcho Lab).  Additional details about the grant can be found on NIH eReporter:  Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain.

The new grant will develop an acoustic radiation force (ARF)-OCE system based on tightly focused ultrasound ‘palpation’, and apply this system for longitudinal in vivo imaging of the mechanical properties of the tumor microenvironment during tumor development.  Further details about the grant can be found at NIH eReporter: Ultrahigh-Resolution Quantitative Optical Coherence Elastography of the Tumor Microenvironment In Vivo

This year our group presented 4 talks (2 talks were jointly with the Xu Group) at SPIE Photonics West:

1.  Lin’s Keynote Presentation in the Optical Elastography conference on Characterizing three-dimensional micromechanical heterogeneities of the extracellular matrix with photonic-force optical coherence elastography
2.  Nikki’s talk in the OCT conference on Resolution-enhanced optical coherence tomography enabled by coherent-average noise suppression
3.  Siyang’s talk in the OCT conference on Closed loop wavefront sensing and correction in mouse brain enabled by computed optical coherence microscopy
4. Xusan’s talk in the Multiphoton Microscopy in the Biomedical Sciences conference on Simultaneous multimodal optical coherence and three-photon microscopy of the mouse brain in the 1700 nm optical window in vivo

Lin’s talk was entitled “High-throughput lightsheet optical manipulation and measurement with optical coherence tomography”.  Further details can be found at https://www.osapublishing.org/abstract.cfm?uri=OCT-2020-OTu1E.4.