The paper, entitled “Obesity-associated Adipose Stromal Cells Promote Invasion of Premalignant Breast Cancer Cells Through ECM Remodeling”, used 4D-OCM to quantify differences in cell-induced extracellular matrix (ECM) deformations between tumor spheroids co-cultured with lean vs. obese adipose stromal cells (ASCs).
Author: Steven Graham Adie
Feb 2020: Jeff and Nikki present talks at SPIE Photonics West on TF-OCM and PF-OCE
Jeffrey A. Mulligan, Lu Ling, Claudia Fischbach-Tesch, Steven G. Adie, “4D traction force optical coherence microscopy for the analysis of tumor spheroid growth and invasion in collagen”.
Nichaluk Leartprapun, Yuechuan Lin, and Steven G. Adie, “Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity”.
Oct 2019: Meiqi’s paper on computed OCM of mouse brain accepted in Journal of Biomedical Optics!
The paper, entitled “Computed optical coherence microscopy of mouse brain ex vivo“, utilizes computational adaptive optics to reconstruct high-resolution volumes from 4X fewer datasets than standard focus-shifting optical coherence microscopy.
Oct 2019: Nikki’s ARF-OCE paper published in Biomedical Optics Express!
The paper, entitled “Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography“, shows that localized ARF excitation with a smaller acoustic focal spot size results in strain elastograms with superior spatial resolution, contrast, and contrast-to-noise ratio.
Oct 2019: Cornell Research story highlighting our group’s work on imaging cancer
Sep 2019: Hiking adventure at Buttermilk State Park (new photos in Gallery)
Check out the new Buttermilk State Park photos listed under “Outdoor adventures around Ithaca” in our Gallery page.
Aug 2019: Lin’s spectroscopic PF-OCE paper accepted in Optics Letters!
July 2019: Nikki’s quantitative PF-OCE paper accepted in Optics Express!
This paper helps establish PF-OCE as a viable tool for quantitative mechanical microscopy.
June 2019: Welcome to our new postdoc Justin Luo
Justin completed his B.S., M.S., and Ph.D. in Biomedical Engineering all from the University of California, Irvine. Advised by Prof. Vasan Venugopalan and Prof. Elliot Botvinick, Justin developed an optical platform for high-throughput investigation and screening of cellular mechanotransduction initiated by laser-induced cavitation. His current research is focused on new implementations of optical coherence microscopy to monitor the collective behavior of cells in response to dynamically modulated mechanical perturbation.