In this paper we introduce a new ‘hybrid adaptive optics’ (hyAO) approach that synergistically combines hardware adaptive optics (HAO) and computational adaptive optics (CAO). We show that hyAO can significantly increase the throughput of large-volume, optical coherence microscopy, and use it to image cell population dynamics over a 1mm × 1mm × 1mm field-of-view with 2 μm isotropic spatial resolution and 3-minute temporal resolution.