This paper presents the use of light-sheet photonic force for parallel mechanical loading, and demonstrates high-throughput quantitative 3D micromechanical imaging. We quantify the micromechanical heterogeneity of fibrous collagen matrices and perform live-cell imaging of cell-mediated ECM micromechanical dynamics. Our 4D imaging of micromechanical dynamics of cell-mediated ECM deformations enabled observations that, to our knowledge, have never been reported by other techniques. For further information check our paper Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging.
Month: June 2022
June 2022: New R01 grant to integrate computational, adaptive optics and other hardware approaches for ultra-deep OCT
This grant proposes to integrate aberration-diverse OCT (an approach recently developed by our group), long wavelength imaging in the 1700nm window, adaptive optics to correct sample-induced aberrations, and complex conjugate spectral-domain OCT to overcome the (current) multiple scattering limit in OCT. For further information see our grant listing at NIH RePORTER Overcoming the Multiple Scattering Limit in Optical Coherence Tomography.