We show that we can use optical radiation pressure from a weakly focused beam to ‘push’ on beads embedded in a viscoelastic medium, and isolate the dynamic displacements from each bead via optical coherence elastography. This allows us to actuate and interrogate the mechanical response from a large number of beads randomly distributed in 3D biological media.
This ability to do time-lapse volumetric mechanical microscopy in viscoelastic media has applications to the study of biophysical cell-ECM interactions, including cell forces and 3D cancer cell migration, the impact of local mechanical properties on single as well as collective cell behavior, and to monitor cell-induced ECM remodeling.
For more information see Leartprapun et al., Photonic force optical coherence elastography for three-dimensional mechanical microscopy”, Nature Communications, 9:2079, 2018.
BME Masters student Byung Wook Ryu joins the group to work on Optical Design and OCT System Characterization
The Department of Biomedical Engineering is pleased to announce that Assistant Professor Steven G. Adie has joined our faculty, beginning July 1, 2013. Adie earned his Ph.D. in Electrical and Electronic Engineering (specializing in Biomedical Optics) from the University of Western Australia in 2007. Most recently he has been a Postdoctoral Research Associate in the Biophotonics Imaging Laboratory at the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign. The Adie lab at Cornell will leverage OCT-based tomography of tissue structure and function to better understand the progression of disease. Of particular interest is the role of mechanics in cancer initiation and tumor development, to help establish the in vivo relevance of in vitro studies on cancer mechanics, and support the long-term goal of improving the diagnosis and treatment of cancer and other diseases.