The paper, entitled “Obesity-associated Adipose Stromal Cells Promote Invasion of Premalignant Breast Cancer Cells Through ECM Remodeling”, used 4D-OCM to quantify differences in cell-induced extracellular matrix (ECM) deformations between tumor spheroids co-cultured with lean vs. obese adipose stromal cells (ASCs).
Jeffrey A. Mulligan, Lu Ling, Claudia Fischbach-Tesch, Steven G. Adie, “4D traction force optical coherence microscopy for the analysis of tumor spheroid growth and invasion in collagen”.
Nichaluk Leartprapun, Yuechuan Lin, and Steven G. Adie, “Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity”.
The paper, entitled “Computed optical coherence microscopy of mouse brain ex vivo“, utilizes computational adaptive optics to reconstruct high-resolution volumes from 4X fewer datasets than standard focus-shifting optical coherence microscopy.
The paper, entitled “Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography“, shows that localized ARF excitation with a smaller acoustic focal spot size results in strain elastograms with superior spatial resolution, contrast, and contrast-to-noise ratio.
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This paper helps establish PF-OCE as a viable tool for quantitative mechanical microscopy.
Justin completed his B.S., M.S., and Ph.D. in Biomedical Engineering all from the University of California, Irvine. Advised by Prof. Vasan Venugopalan and Prof. Elliot Botvinick, Justin developed an optical platform for high-throughput investigation and screening of cellular mechanotransduction initiated by laser-induced cavitation. His current research is focused on new implementations of optical coherence microscopy to monitor the collective behavior of cells in response to dynamically modulated mechanical perturbation.