This paper helps establish PF-OCE as a viable tool for quantitative mechanical microscopy.
Justin completed his B.S., M.S., and Ph.D. in Biomedical Engineering all from the University of California, Irvine. Advised by Prof. Vasan Venugopalan and Prof. Elliot Botvinick, Justin developed an optical platform for high-throughput investigation and screening of cellular mechanotransduction initiated by laser-induced cavitation. His current research is focused on new implementations of optical coherence microscopy to monitor the collective behavior of cells in response to dynamically modulated mechanical perturbation.
In this paper we demonstrate quantitative TF-OCM for reconstruction of 3D cell forces with minute-scale temporal resolution. Due to the ability of computational OCM to perform large-scale volumetric and label-free imaging in scattering media, TF-OCM may prove advantageous for the study of the force dynamics of large cell collectives in the burgeoning field of mechanobiology.
Lin obtained his B.Sc from Nankai University in 2013 and his Ph.D from The Hong Kong Polytechnic University in 2018, under the supervision of Prof. Wei Jin. During his Ph.D studies, he explored novel ultra-sensitive optical spectroscopy techniques, especially the microstructure-enhanced photothermal spectroscopy in photonic crystal fibres. His current research focuses on new approaches for photonic force optical coherence elastography, and quantitative investigations of mechanical properties for stem cell mechanobiology research.