The new grant will develop an acoustic radiation force (ARF)-OCE system based on tightly focused ultrasound ‘palpation’, and apply this system for longitudinal in vivo imaging of the mechanical properties of the tumor microenvironment during tumor development. Further details about the grant can be found at NIH eReporter: Ultrahigh-Resolution Quantitative Optical Coherence Elastography of the Tumor Microenvironment In Vivo