This new grant will support our collaborative research with the Xu Group on the development of multimodal hybrid adaptive optics. We seek to utilize computational adaptive optics (CAO)-OCT as a deep-tissue aberration sensor, together with the close connection between hardware AO and CAO, to enable AO three-photon microscopy (AO-3PM) image faster and deeper in the mouse and adult zebrafish brain (collaboration with the Fetcho Lab). Additional details about the grant can be found on NIH eReporter: Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain.