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Lin obtained his B.Sc from Nankai University in 2013 and his Ph.D from The Hong Kong Polytechnic University in 2018, under the supervision of Prof. Wei Jin. During his Ph.D studies, he explored novel ultra-sensitive optical spectroscopy techniques, especially the microstructure-enhanced photothermal spectroscopy in photonic crystal fibres. His current research focuses on new approaches for photonic force optical coherence elastography, and quantitative investigations of mechanical properties for stem cell mechanobiology research.

Siyang’s recent hybrid adaptive optics paper published in Biomedical Optics Express has been highlighted as an Editor’s Pick.

Editor’s Picks serve to highlight articles with excellent scientific quality and are representative of the work taking place in a specific field.

Click on the link to go to the Cornell Chronicle’s article entitled New microscopy method could benefit study of migrating cancer cells.

In this paper we introduce a new ‘hybrid adaptive optics’ (hyAO) approach that synergistically combines hardware adaptive optics (HAO) and computational adaptive optics (CAO).  We show that hyAO can significantly increase the throughput of large-volume, optical coherence microscopy, and use it to image cell population dynamics over a 1mm × 1mm × 1mm field-of-view with 2 μm isotropic spatial resolution and 3-minute temporal resolution.

In collaboration with the Cosgrove Lab, the proposed research will utilize novel OCE methods for 3D mechanical microscopy to investigate the role of local mechanical properties of individual stem cell microenvironments in intact tissue explants and engineered biomaterial niches.

Nikki’s and Rishee’s paper on the ‘OCT version’ of Ashkin’s seminal radiation pressure experiment is now published in Optics Express.

Depth-resolved measurement of optical radiation-pressure forces with OCT may find applications in the characterization of optical tractor beams over extended depth ranges, or volumetric optical manipulation and interrogation of beads in viscoelastic media.

Entitled “CAREER: Hybrid adaptive optics: a new paradigm for faster, deeper, volumetric microscopy in scattering media”, this was awarded through the NSF BIOPHOTONICS, IMAGING & SENSING programs.  Further information can be found on the NSF website.

Raisa B. Rasul is a PhD student in the Biomedical Engineering Department. She obtained her B.S. in Biomedical Engineering with a minor in Nanotechnology from the University of Arkansas. Her research in the group is focused on the use of optical elastography to study cancer and stem cell mechanobiology.

J.A. Mulligan, F. Bordeleau, C.A. Reinhart-King and S.G. Adie, “Traction Force Microscopy for Non-Invasive Imaging of Cell Forces”, In Biomechanics in Oncology, Editors: C. Dong, N. Kuhn, and K. Konstantopoulos, Springer, In press.