Lin obtained his B.Sc from Nankai University in 2013 and his Ph.D from The Hong Kong Polytechnic University in 2018, under the supervision of Prof. Wei Jin. During his Ph.D studies, he explored novel ultra-sensitive optical spectroscopy techniques, especially the microstructure-enhanced photothermal spectroscopy in photonic crystal fibres. His current research focuses on new approaches for photonic force optical coherence elastography, and quantitative investigations of mechanical properties for stem cell mechanobiology research.
July 2018: Siyang’s hybrid adaptive optics paper selected as Editor’s Pick!
Siyang’s recent hybrid adaptive optics paper published in Biomedical Optics Express has been highlighted as an Editor’s Pick.
Editor’s Picks serve to highlight articles with excellent scientific quality and are representative of the work taking place in a specific field.
June 2018: Our PF-OCE work featured in the Cornell Chronicle!
Click on the link to go to the Cornell Chronicle’s article entitled New microscopy method could benefit study of migrating cancer cells.
June 2018: Siyang’s ‘hybrid adaptive optics’ paper published in Biomedical Optics Express!
In this paper we introduce a new ‘hybrid adaptive optics’ (hyAO) approach that synergistically combines hardware adaptive optics (HAO) and computational adaptive optics (CAO). We show that hyAO can significantly increase the throughput of large-volume, optical coherence microscopy, and use it to image cell population dynamics over a 1mm × 1mm × 1mm field-of-view with 2 μm isotropic spatial resolution and 3-minute temporal resolution.
May 2018: Our PF-OCE paper published in Nature Communications!
We show that we can use optical radiation pressure from a weakly focused beam to ‘push’ on beads embedded in a viscoelastic medium, and isolate the dynamic displacements from each bead via optical coherence elastography. This allows us to actuate and interrogate the mechanical response from a large number of beads randomly distributed in 3D biological media.
This ability to do time-lapse volumetric mechanical microscopy in viscoelastic media has applications to the study of biophysical cell-ECM interactions, including cell forces and 3D cancer cell migration, the impact of local mechanical properties on single as well as collective cell behavior, and to monitor cell-induced ECM remodeling.
For more information see Leartprapun et al., Photonic force optical coherence elastography for three-dimensional mechanical microscopy”, Nature Communications, 9:2079, 2018.
May 2018: Siyang passes his A-exam!
Mar 2018: Prof. Adie wins NIBIB Trailblazer Award
In collaboration with the Cosgrove Lab, the proposed research will utilize novel OCE methods for 3D mechanical microscopy to investigate the role of local mechanical properties of individual stem cell microenvironments in intact tissue explants and engineered biomaterial niches.
Jan 2018: Nikki and Rishee’s paper published in Optics Express!
Nikki’s and Rishee’s paper on the ‘OCT version’ of Ashkin’s seminal radiation pressure experiment is now published in Optics Express.
Depth-resolved measurement of optical radiation-pressure forces with OCT may find applications in the characterization of optical tractor beams over extended depth ranges, or volumetric optical manipulation and interrogation of beads in viscoelastic media.
Dec 2017: Prof. Adie wins NSF CAREER Award
Entitled “CAREER: Hybrid adaptive optics: a new paradigm for faster, deeper, volumetric microscopy in scattering media”, this was awarded through the NSF BIOPHOTONICS, IMAGING & SENSING programs. Further information can be found on the NSF website.
Dec 2017: The group welcomes new PhD student Raisa Rasul
Rai
sa B. Rasul is a PhD student in the Biomedical Engineering Department. She obtained her B.S. in Biomedical Engineering with a minor in Nanotechnology from the University of Arkansas. Her research in the group is focused on the use of optical elastography to study cancer and stem cell mechanobiology.