This new grant will support our collaborative research with the Xu Group on the development of multimodal hybrid adaptive optics. We seek to utilize computational adaptive optics (CAO)-OCT as a deep-tissue aberration sensor, together with the close connection between hardware AO and CAO, to enable AO three-photon microscopy (AO-3PM) image faster and deeper in the mouse and adult zebrafish brain (collaboration with the Fetcho Lab). Additional details about the grant can be found on NIH eReporter: Real-time Aberration Sensor for Large-Scale Microscopy Deep in the Mouse and Adult Zebrafish Brain.
Month: May 2021
May 2021: New R21 grant for ultrahigh-resolution ARF-OCE
The new grant will develop an acoustic radiation force (ARF)-OCE system based on tightly focused ultrasound ‘palpation’, and apply this system for longitudinal in vivo imaging of the mechanical properties of the tumor microenvironment during tumor development. Further details about the grant can be found at NIH eReporter: Ultrahigh-Resolution Quantitative Optical Coherence Elastography of the Tumor Microenvironment In Vivo